Sodium monofluorophosphate (MFP) is a widely recognized and effective dental care ingredient, particularly in toothpaste and other oral hygiene products. It is valued for its ability to provide a controlled release of fluoride ions, which are essential for strengthening tooth enamel and protecting against cavities. MFP is considered safe and effective, with a long history of use in dental care products.
MFP's chemical structure includes tetrahedral \[PO3F\]− structural units with an intact P-F bond, which is subject to hydrolysis through the actions of phosphatase enzymes in vivo, liberating free fluoride anion and inorganic orthophosphate. This process is rapid in the small intestine and liver but slower in the blood, contributing to its low acute toxicity and lack of gastric irritation associated with its use.
In addition to its primary use in oral care, MFP has been found to inhibit the solubility of lead in drinking water, making it a useful compound in water treatment applications. It is also used in some medications for the treatment of osteoporosis, highlighting its versatility beyond dental care.
When used in toothpaste, MFP is typically combined with other ingredients to enhance its efficacy and safety, contributing to overall oral hygiene. Its mild taste and compatibility with various toothpaste formulations make it a preferred choice for dental care products. The effectiveness of MFP in remineralizing teeth and preventing demineralization is well-established, and it is often recommended for sensitive teeth due to its less abrasive nature.